The Indo-Pacific region has emerged as a central focus of global geopolitics, with the United States playing a pivotal role in shaping its strategic landscape. This article examines the evolution of the U.S. Indo-Pacific strategy across different administrations, highlighting the elements of continuity and change. From the Obama administration's "Pivot to Asia" to Trump’s "Free and Open Indo-Pacific" framework and Biden’s enhanced emphasis on alliances, each administration has adapted its approach to address shifting regional dynamics. The article delves into the implications of these strategies for India, a key player in the region, analysing opportunities for collaboration in defence, trade, and regional stability, as well as challenges posed by strategic divergences and India's commitment to strategic autonomy. By evaluating the broader regional and global impacts, the article underscores the significance of India’s role in navigating the evolving Indo-Pacific narrative and its potential to shape a multipolar order.