The rapid development of Information and Communication Technologies (ICT) is an asset for e-learning. This is a new form of distance education that relies on the Internet and the Web. This new pedagogical approach promote that the learner is the protagonist of his/her own training and thereby put in range that he/she needs to complete his/her apprenticeship. These resources are made available on the platform by the trainers. Unfortunately, in the majority of e-learning platforms, the course is offered, regardless of the state of the learner (disability, level of education, age, etc ...). Many people thus excluded from e-learning. This somewhat mitigates e-learning possibilities. According to world statistics, 10% of the world population, about 650 million people, lives with disability [1]. The promotion of employment for all, advocated by human rights, will dwell on this mode of learning to train all young people who for many reasons do not always have the opportunity to attend a campus training center. E-learning should also be available to disable persons such as blinds, deafs, mutes,… This work develops new interfaces that adapt according to knowledges of the learner to facilitate e-learning. The illiteracy rate is therefore reduce in its simplest form.